Skin is the body’s largest organ, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System think it may be to blame for body-wide inflammation linked to numerous chronic diseases of aging. The good news is that properly caring for the skin with a moisturizing cream may lower inflammation levels and potentially reduce the risk of a number of age-related diseases, according to a new clinical pilot study. As humans get older, we experience a low-level of inflammation—dubbed “inflamm-aging”—driven by an increase in molecules in the blood called cytokines. This age-related inflammation has been linked to serious chronic diseases, including Alzheimer’s disease, cardiovascular disease, and diabetes. Scientists initially thought that the inflammation stemmed from the immune system or the liver, but a group of dermatologists at UCSF have a different theory.