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The Link Between Human Evolution And Hepatitis C Virus

As humans evolved, they developed a vulnerability to hepatitis C virus (HCV), but according to new research a small group of humans appears to have avoided the deficit. That’s the central finding of new research that looked into the evolution of the interferon lambda 4 (IFNL4) in humans. Study co-authors John McLauchlan, PhD, and Connor Bamford, PhD, both of the University of Glasgow, told MD Magazine that IFNL4 doesn’t respond to HCV the way one would expect. “Typically, you would expect that an interferon gene will act against any virus but in this case, IFNL4 appears to promote the development of chronic infection after an acute phase of infection,” said the investigators.

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